Imetelstat inhibits growth of megakaryocyte colony-forming units from patients with essential thrombocythemia
نویسندگان
چکیده
منابع مشابه
Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia.
BACKGROUND Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits telomerase enzymatic activity. It has been shown to inhibit megakaryocytic proliferation in vitro in cells obtained from patients with essential thrombocythemia. In this phase 2 study, we investigated whether imetelstat could elicit hematologic and molecular responses in pat...
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To the Editor: Baerlocher et al. (Sept. 3 issue)1 report on telomere-targeted treatment with imetelstat in 18 patients with essential thrombocythemia. The drug was effective in controlling platelet levels in all patients, albeit often at the expense of hemoglobin and neutrophil levels. However, the other main treatment goals in essential thrombocythemia2 — controlling symptoms and preventing bo...
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Calreticulin (CALR) is a multifaceted protein primarily involved in intracellular protein control processes. The identification of CALR mutations in essential thrombocythemia (ET) and primary myelofibrosis that are mutually exclusive with the JAK2 V617F mutation has stirred an intensive research interest about the molecular functions of CALR and its mutants in myeloproliferative neoplasms (MPNs...
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Peripheral blood mononuclear cells from five patients with essential thrombocythemia (ET) were cultured in vitro to evaluate restricted megakaryocytic (CFU-Meg), myeloid (CFU-GM), and erythroid (BFU-E) progenitor cell development. Varying concentrations of aplastic canine serum served as the source of megakaryocyte colony-stimulating activity, and cultured megakaryocyte ploidy distributions wer...
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To investigate the feasibility of using tissue obtained from human tumor xenografts for in vitro screening of antineoplastic agents, we grew human tumor colony-forming units (CFU) in semisold agar from xenografts serially passaged in nude mice. Growth of human tumor CFU was accomplished from nine xenografts representing five different histological tumor types (ovarian carcinoma, adenocarcinoma ...
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ژورنال
عنوان ژورنال: Blood Advances
سال: 2019
ISSN: 2473-9529,2473-9537
DOI: 10.1182/bloodadvances.2019000167